SUMMARY OF ARTICLE

ABSTRACT

Antimicrobial resistance (AMR) crisis is a global multifaceted and perilous situation, which is posing a grave challenge for the medical fraternity by making the eradication of deadly pathogens a difficult task. Antibiotics abuse in human medicine as well as various fields of agriculture and allied sectors has led to change in the econiche of pathogens making them resistant to the same antimicrobials which were found effective earlier. Further exploiting the broad spectrum antibiotics or consortium of discrete antibiotics to mitigate developed resistance might binate the resistance pattern among pathogens through the phenomena of microbial adaptation. To address these issues, probiotics can be exploited as biotherapeutic augmented approach to decolonize the Multidrug Resistant (MDR) pathogens from gut econiche and subsequently to ameliorate the pathological conditions in host. Probiotics compete for nutrition and binding sites in gut beyond showing antagonism against superbugs. Further synergistic effect of probiotics by production of biosurfactants and subsequent ability to disrupt the quorum sensing phenomenon of pathogens can result in amelioration of virulence gene and other adhesion related gene expression by pathogens creating an inappropriate environment for MDR pathogens to survive in the gut.